ABSTRACT
Metabolic syndrome represents a cluster of metabolic abnormalities that includes hypertension, obesity, insulin resistance, cardiovascular, immune diseases and atherogenic yslipidemia, so we are a need for new dietary, lifestyle, and therapeutic options, include fasting emerged as a dietary method proposed for controlling metabolic risk factors. Intermittent fasting has gained attention as a diet for endemic diseases to metabolic health, hence there has been an increasing search to develope innovative therapies to decrease spread metabolic diseases. So this research was aimed the effectiveness of a suggested indicative program to measure cognitive experiences towards the importance of intermittent fasting regimen and its impact on endemic diseases in Najran region. Thirty volunteers persons from Najran region to awareness them towards the importance of intermittent fasting regimen and its impact on endemic diseases, the results showed that volunteers not have any awareness about the health benefits of intermittent fasting toward endemic diseases, thus, due to the awareness, increased them awareness about the intermittent fasting particularly, obesity, diabetic, and blood pressure diseases. The results have showed reduction and improvement post the intermittent fasting in the parameters such as, body weight from 95±1 to 68±1 kg, body mass index from 37. 58±1 to 25.1±1.1 kg/m2. Also, The laboratory results have showed reduction and improvement in blood glucose level from 170.5±1.8/ 95±2.0 to 126±0.2/79±0.1 mg/dl, triglycerides from 230.4±3.0 to 201±1 mg/dl, total cholesterol from 237.9±1.2 to 198±1.2 mg/dl, uric acid from 9.3±0.1 to 3.6±0.2 mg/dl, Creatinine 0.9±0.11 to 0.72±0.2 mg/dl, ALT from (31.6±1.1 to 14±0.2 U/L, AST from 23.5±0.8 to 13.5±0.1 U/L and blood pressure level from 159±2/ 110±3 to 123±1/ 86±1.1 mm/Hg respectively. Conclusion: This research recommended by using the intermitted fasting diet as lifestyle due to its importance of endemic diseases as diabetic, obesity, blood pressure also immune diseases as cancer and covid-19. Also, it is one tool which has been proposed by health experts due to its benefits on weight management and cardiovascular health. © NSP 2023 Natural Sciences Publishing Cor.
ABSTRACT
Introduction Coronaviruses are a large family of viruses that lead to diseases in animals or humans. Objective To assess clinical, radiological, and laboratory criteria, as well as treatment of patients hospitalized with coronavirus disease 2019, and the relation to radiological progression and hospital stay. Patients and methods This study was a prospective observational study conducted in an isolation sector in a private hospital in Saudi Arabia. Data were obtained from electronic records. Results A total of 30 patients were enrolled (24 males and six females), and their mean age was 51.2±15.05 years. The presenting symptoms were fever (83.3%), cough (33.3%), shortness of breathing (26.7%), body aches (16.7%), and sore throat (10%). Chest radiograph was abnormal in 76.6%. C-reactive protein (CRP) was high at 112.59±140±0.50 mg/l, and serum ferritin was 763.21±652.18 μg/l. Lactate dehydrogenase (LDH) was higher than normal at 312.86±161 U/l. Mean D-dimer was 0.97±1.11 μg/ml. international normalized ratio was 1.09±0.194. Fibrinogen was high at 575.32±220.08 mg/dl, and activated partial thromboplastin time was 37.94±17.46 s. There was a strong positive correlation between serum ferritin and temperature, LDH, and aspartate transaminase. CRP had a strong positive correlation with alanine transaminase, total leukocytic count, lymphocytes, and neutrophil/lymphocyte ratio. Hospital stay was positively correlated with ferritin. LDH was negatively correlated with lymphocytic count. The correlation between radiological course and laboratory follow-up was poor. Conclusion Coronavirus disease 2019 affects males more than females and is more in elderly. Fever is a common presenting symptom. Infection affects many blood indices, such as LDH, ferritin, CRP, and fibrinogen. Radiological course of the lesions is not affected by those blood indices, whereas hospital stay is affected. The outcome is favorable in most of the patients.
ABSTRACT
Background: Patients with diabetes mellitus infected with the new coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are at risk of high morbidity and mortality. Objective: Our study aimed to address the clinical, laboratory and radiological predictors of hospital admission course for patients with diabetes mellitus with COVID19 infection at the time of admission. Patients and Methods: This was a single center, retrospective study of patients with diabetes mellitus (DM) admitted with COVID-19 infection. Patients with unfavorable admission course were compared with those of favorable course regarding patient characteristics, clinical presentation, results of laboratory investigations and chest CT severity score. Univariate and multivariate analysis associated with the unfavorable course was performed. Results: Among 141 patients with DM admitted with COVID19, 44 patients had unfavorable course. Those with the favorable course were significantly younger (53.3±16.4) vs (67.3 ±15.8) in the unfavorable course group, multivariate analysis revealed that age more than 65, presence of hypertension, CT severity scoring, high HBA1c, AST, IL6, oxygen saturation less than 93% and low lymphocyte count were the independent predictors of the unfavorable hospital admission course. Conclusions: Our finding suggests that old age, presence of hypertension, hypoxia at presentation, in addition to high HBA1c, AST, IL6, CT severity scoring and low lymphocyte count were significant predictors of unfavorable admission course in COVID19 patients with diabetes. © 2021, Ain Shams University Faculty of Medicine. All rights reserved.